Nucleolar URB1 ensures 3'ETS rRNA removal to prevent exosome surveillance

摘要

The nucleolus is the most prominent membraneless condensate in the nucleus.It comprises hundreds of proteins with distinct roles in the rapid transcription of ribosomal RNA(rRNA)and efficient processing within units comprising a fibrillar centre and a dense fibrillar component and ribosome assembly in a granular component1.The precise localization of most nucleolar proteins and whether their specific localization contributes to the radial flux of pre-rRNA processing have remained unknown owing to insufficient resolution in imaging studies2-5.