伊立替康联合顺铂新辅助化疗对局部晚期宫颈癌患者生活质量影响

摘要

目的 分析伊立替康联合顺铂新辅助化疗对局部晚期宫颈癌患者生活质量影响.方法 收集我院2016年3月至2017年3月局部晚期宫颈癌患者共120例,按随机数字表法分为常规组(60例)和试验组(60例),常规组接受同步放化疗,试验组接受伊立替康联合顺铂新辅助化疗,将2组患者的疗效进行观察和对比.结果 试验组患者治疗总有效率为83%(50/60),常规组患者治疗总有效率为68%(41/60),试验组患者治疗效果显著优于常规组(P <0.05);试验组患者治疗后生活质量评分为(48.3 ± 2.5)分,常规组治疗后生活质量评分为(41.3 ± 2.0)分,试验组生活评分高于常规组(P <0.05).结论 针对局部晚期宫颈癌患者运用伊立替康联合顺铂新辅助化疗治疗效果显著优于传统同步化疗,能够提升患者的治疗效果,同时改善生活质量.%Objective To analyze the effect of neoadjuvant chemotherapy with irinotecan combined with cis-platin on the quality of life in patients with locally advanced cervical cancer.Methods A total of 120 patients with locally advanced cervical cancer were collected from March 2016 to March 2017 in our hospital.According to the principle of randomization,the patients were divided into conventional group(60 cases)and experimental group (60 cases).The conventional group received concurrent chemoradiotherapy.The experimental group received iri-notecan plus cisplatin neoadjuvant chemotherapy,the efficacy of the two groups of patients were observed and compared.Results The total effective rate was 83%(50/60)in the experimental group and 68%(41/60)in the conventional group.The treatment effect in the experimental group was significantly better than that in the con-ventional group(P <0.05).The quality of life score of the experimental group was 48.3 ± 2.5 after treatment, the quality of life score of the conventional group was 41.3 ± 2.0,the life score of the experimental group was higher than that of the conventional group(P<0.05).Conclusion For locally advanced cervical cancer patients, irinotecan combined with cisplatin neoadjuvant chemotherapy was significantly better than the traditional synchro-nous chemotherapy.It can improve the patient′s treatment,while improving quality of life.