针刺对功能性消化不良患者心理因素及血清Ghrelin水平的影响

摘要

Objective To investigate the effect of acupuncture on the mental health score and serum ghrelin levels in patients with functional dyspepsia (FD).Methods Sixty-eight FD patients were randomized to treatment and control groups, 34 cases each. The treatment group received acupuncture and the control group took domperidone tablets orally. The TCM symptom score and the Symptom Checklist-90 (SCL-90) subscores were recorded and serum ghrelin levels were measured in the two groups before and after treatment.Results There were statistically significant pre-/post- treatment differences in the TCM symptom score and serum ghrelin level in the two groups (P<0.05). There was a statistically significant post-treatment difference in the TCM symptom score between the treatment and control groups (P<0.05). There were statistically significant pre-/post-treatment differences in the SCL-90 somatization, obsessive- compulsive disorder, interpersonal sensitivity, depression, anxiety and psychotic factor subscores in the treatment group (P<0.05). There was a statistically significant pre-/post-treatment difference in the somatization subscore in the control group (P<0.05). There were statistically significant post-treatment differences in the interpersonal sensitivity, depression and anxiety subscores between the treatment and control groups (P<0.05). In FD patients there was a negative correlation of the ghrelin level with the SCL-90 somatization, obsessive-compulsive disorder, interpersonal sensitivity, depression and anxiety subscores (P<0.05).Conclusions Acupuncture can reduce the clinical symptomsand psychological problems in FD patients. Its mechanism of action may be related to raising serum ghrelin levels.%目的 观察针刺对功能性消化不良(FD)患者心理健康评分及血清胃促生长素(Ghrelin)水平的影响.方法 将68例FD患者随机分为治疗组和对照组,每组34例.治疗组采用针刺治疗,对照组采用口服多潘立酮片治疗.观察两组治疗前后中医症状评分、症状自评量表(SCL-90)各因子评分及血清Ghrelin水平的变化情况.结果 两组治疗后中医症状评分及血清Ghrelin水平与同组治疗前比较,差异均具有统计学意义(P<0.05).治疗组治疗后中医症状评分与对照组比较,差异具有统计学意义(P<0.05).治疗组治疗后SCL-90中躯体化、强迫症状、人际关系敏感、抑郁、焦虑、精神病性因子评分与同组治疗前比较,差异均具有统计学意义(P<0.05).对照组治疗后躯体化因子评分与同组治疗前比较,差异具有统计学意义(P<0.05).治疗组治疗后人际关系敏感、抑郁、焦虑因子评分与对照组比较,差异具有统计学意义(P<0.05).FD患者治疗前后Ghrelin水平与SCL-90中躯体化、强迫症状、人际关系敏感、抑郁、焦虑因子评分存在负相关,具有统计学意义(P<0.05).结论 针刺能改善FD患者临床症状和精神心理问题,其作用机制可能与升高血清Ghrelin水平有关.