肝细胞癌组织中Cyr61、VEGF和HSP27的表达及意义

摘要

目的 观察富半胱氨酸蛋白61(Cyr61)、血管内皮生长因子(VEGF)和热休克蛋白27(HSP27)在肝细胞癌(HCC)中的表达,分析其与HCC病理学特征和转移的关系.方法 采用免疫组化SP法分别检测34例HCC患者肝癌组织和癌旁肝组织中的Cyr61、VEGF和HSP27表达情况,并与HCC患者的临床、病理学特征进行相关性分析.结果 VEGF和HSP27在肝癌组织中的表达显著高于癌旁组织(P＜0.05),Cyr61在癌旁组织中的表达显著高于肝癌组织(P＜0.05);HCC转移者的Cyr61、VEGF和HSP27阳性表达率明显高于无转移者(P＜0.05).结论 Cyr61、VEGF和HSP27的表达与HCC转移密切相关;联合检测Cyr61、VEGF和HSP27的表达情况对判断HCC转移和预后有一定的临床价值.%Objective To investigate the relationship of Cyr61 ,VEGF and HSP27 with the pathological properties and metastasis of hepatocellular carcinoma(HCC). Methods The expression of Cyr61 ,VEGF and HSP27 was detected by immunohistochemistry assay(SP) in 34 hepatocellular carcinoma and its para-neoplastic liver tissue. Results The expression rates of VEGF and HSP27 were significantly higher in the hepatocellular carcinoma than those in para-neoplastic liver tissue ( P ＜ 0.05 ). The level of expression of Cyr61 was significantly higher in the para-neoplastic liver tissue than that in hepatocellular carcinoma(P ＜0.05), The expression rates of Cyr61 ,VEGF and HSP27 were significantly higher in HCC with metastasis than those in HCC without metastasis(P ＜0.05). Conclusions The expression of Cyr61 ,VEGF and HSP27 may be play an important role in hepatocellular carcinogenesis and be correlated to metastasis of the hepatocellular carcinoma.The expression of Cyr61 ,VEGF and HSP27 may have important value in determining metastasis and prognosis of HCC.