目的：对糖尿病（DM）患者血糖三项[餐前血糖、餐后2 h血糖、糖化血红蛋白（HbA1c）]和临床信息进行数据挖掘，评估血糖三项诊断DM的价值。方法回顾性分析泸州地区7614例中老年人血糖三项检测结果及诊断信息，参考美国临床实验室标准化委员会C28-A2文件推荐方法估计55～62岁人群中血糖三项的参考区间，构建诊断和筛查DM的受试者工作曲线（ ROC）数据集，用验后概率来扩展Roc数据集。结果55～62岁人群血糖三项的参考区间分别为：餐前血糖3．89～6．64 mmol/L，餐后2 h血糖4．11～7．73 mmol/L，HbA1c ＜6．2％；血糖三项对DM的诊断价值为餐后2 h血糖＞餐前血糖＞HbA1c ，其ROC下面积分别为0．975、0．887、0．849。诊断DM的切点：餐前血糖6．8 mmol/L；餐后2 h血糖11．0 mmol/L，HbA1c ＜6．2％。经临床实践验证，餐前血糖诊断DM符合率为83．02％，餐后2 h血糖为95．57％。结论血糖三项检验数据挖掘明显提高了DM的诊断价值。%Objective To analyze the three items of blood glucose [ fasting plasma glucose ( FPG) , 2 h postprandial glucose (2 h PG) and hemoglobinA1c (HbA1c)] and clinical information deeply, to evaluate their reference ranges and thus to provide the valuable diagnostic information for patients with diabetes mellitus ( DM) .Methods According to the file of C28-A2 at clinical laboratory standardization committee , we retrospectively analyzed three items and diagnostic infor-mation of 7 614 elders in Luzhou , and established the reference ranges of three terms and built the receiver operating char-acteristic curve ( ROC) to diagnose DM and assess diagnosis values .Results The reference ranges of FPG , 2 h PG and HbA1c were 3.89-6.64 mmol/L, 4.11-7.73 mmol/L and HbA1c <6.2%, respectively.The ranks of diagnosis value for DM by FPG, 2 h PG and HbA1c were 2 h PG>FPG>HbA1c, and the area under ROC (AUC) were 0.975, 0.887 and 0.849, respectively.The point of tangency in diagnosis of DM was FPG , 6.8 mmol/L;2 h PG, 11.0mmol/L and HbA1c<6.2%.The diagnostic coincidence rate of FBPG was 83.02%, and 2 h PG was 95.57%.Conclusion The data min-ing of three items of blood glucose significantly improves the DM diagnostic value .
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