表皮生长因子样因子在LH峰效应中的作用及临床研究进展

摘要

表皮生长因子样因子(epidermal growth factor-like factor)——双调蛋白(amphiregulin,Areg)、上皮调节蛋白(epiregulin,Ereg)和细胞调节素(betacellulin,BTC)通过旁分泌和自分泌方式介导黄体生成素(luteinizing hormone,LH)峰效应,从而诱导卵母细胞减数分裂恢复、卵丘扩展以及排卵.%Epidermal growth factor-like factors-amphiregulin (Areg),epiregulin (Ereg) and betacellulin (BTC) play an essential role in mediating luteinizing hormone (LH) surge effect through paracrine and autocrine ways,resulting in oocyte meiotic resume,cumulus expansion and ovulation.