Relieving the Impacts of Oral Contraceptives on Lipids Profile by Taking Pills in a Novel Scheme

摘要

Objective To explore whether the changes on lipids profile induced by oral contraceptives could be reduced through alternatively administering two oral contraceptives of different formulations (either predominant in progestogen or estrogen) Materials & Methods A total of 59 women aged 25～45 were divided into two treatment groups. The subjects in Group A received oral contraceptive A (OcA: NET 0.600 mg + EE 0.035 mg) and B (OcB: LNG 0.15 mg + EE0.03 mg) alternatively during 12 treatment cycles. Each contraceptive was administrated for three cycles consecutively with starting from OcA. The subjects in the B group received OcB only during 12 treatment cycles. Fasting blood were drawn before treatment, at the end of each trimester treatment and at the end of one cycle after stopping treatment respectively. The concentrations of lipids and apolipoproteins were measured. Results OcA increased the levels of triglyceride(TG), total cholesterol(TC), high density lipoprotein-cholesterol(HDL-c), and apolipoprotein AI (apo AI) with statistical significance, whereas OcB significantly decreased all parameters above. As compared with the control group, the overall mean of variation in the study group was much less than that of the control group.Conclusion It indicates that the impacts of oral contraceptives on lipids profile could be moderated by means of alternatively administering Ocs of two different formulations, with estrogen-dominant or progestogen-dominant.