Correlation between Copper Ion Concentration in Cervical Mucus and Fllbrinolytic Activity in Menstrual Blood in Copper-releasiag IUD Users

摘要

In the present study, 44 women using TCu220c-IUD or inert-IUD were asked to make follow-ups before insertion and at the 1st., 3rd., 6th, 9th and 12th month after insertion The mean menstrual blood loss, the fibrinalytic activity including the activation of tissue-plasminogen activator (t-PA) and the amount of plasminogen PIG) and fibrinogen-fibrin degradation products (FDP) in menstrual blood and the copper ion concentration in cervical mucus were determined. The correlation between the copper ion concentration and the fibrinalytic activity was considered. It was found that the change of the copper ion concentration was positively correlated with that of the activition of t-PA and the amount of FDP. On the contrary, the change ofthe copper ion concentration was inversely related to the change of PLG value. It is concluded that the high copper ion level can enhance the activation of fibrinolytic system in human endometrium and induce the increase of menorrhagia.