The effect of an once-a-month injectable contraceptive ( Norethisterone enanthate 50mg plas estradiol valerate 5mg ) on lipids metabolism was evaluated in 22 Chinese women. Other 20 women served as control group. Fasting blood samples were taken at the pre-treatment cycle, the cycles afier first, third, sixth and twelfth month during one year treatment and one post-treatment cycle. The changes of the total cholesterol, total triglycerides, HDL-cholesterol and LDL-cholesterol and the ratio of HDL-C / LDL-C were observed. The results showed that the total cholesterol at the 1st and 3rd month of treatment was significantly decreased (P< 0.01) as comparedwith that of pretreatment value and control group. The HDL-cholesterol and totaltriglycerides were also significantly decreased ( P< 0.05) from the 1st to 12th treatment cycle. After discontinuation, total cholesterol, total triglycerides and HDL-cholesterol recovered to the pretreatment levels. The LDL-cholesterol remained unchanged during the whole course. This study suggests that the monthiy injectable contraceptive induces the change in lipid metabolism without significant changes for HDL-C / LDL-C ratio. Although the lipids level occurred to change in the treatment cycle, it recovered quickly at discontinuation of injection. These alterations may be contributed to the functionof body regulation. It can be concluded that there is no obvious relationship between NET-OEN plus EV and CVD.
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