Review of Obstetrics and Perinatal Outcome of Multiple Pregnancies with Vanishing and Selective Embryo Reduction in an Oocyte Donation Program

摘要

Objective To check previous findings of the most common complications among pregnancies with vanishing embryo(VE) in another actual study retropective and in group of patiens with selective embryo reduction (SER) Methods We defined vanishing phenomenon as the spontaneous loss of one or more embryos after visualizing heart activity at the first trimester of pregnancy. Selective embryo reduction was performed between 8th-12th pregnancy week, through vaginal punction and aspiration of embryonic mass. Results Vanishing embryo was observed in 86 patients (18.0%). In 61 patients (70.9%) this phenomenom happened before 9th pregnancy week. The incidence of VE increased with higher number of gestational sacs initially visualized (P<0.03). First trimester bleeding was more common among pregnancies with VE than in the control (P<0.005). The incidence of pregnancy induced hypertension was lower in pregnancies with VE than in the controls (P<0.03). In contrast, preterm spontaneous rupture of membranes was higher, although without statistical significance. Gestational age at delivery, mode of delivery and birth weight was similar in the group of VE and the controls (P=NS). Conclusion All these informations may be useful in counselling patients on the prognosis and outcome of pregnancies achieved by oocyte donation.