Endometrial Prostaglandins in Menstrual Cycle and Early Pregnancy：Effects of Antigestogens

摘要

Antigestogens such as mifepristone oppose the action of endogenous progesteroneby blocking the progesterone receptor in the uterus. There is a modest increase in thecapacity of endonterium from the luteal phase of the cyele and.from decidua of early pregnancy to generate prostaglandins after the administration of antigestogens. Coup-led with a decrease in the metabolism of prostaglandins, this may lead to an increase inconcentration of PGF, and other prostaglandins which cause myometrial contractionsand decidual necrosis.