The Effects of Sino - implant Containing LNG on Lipoprotein Metabolism and Changes in Blood HDL2-C Levels

摘要

The effects of the domestically manufactured contraceptive, Sino-implant containing LNG on various lipids, lipoproteins, apolipoproteins and the HDL2-C levels were evaluated in 20 healthy reproductive-aged volunteers, during cycles after implantation. Results show that the levels of lipids, lipoproteins and apolipoproteins were reduced to different degrees during the 12 treatment cycles. A significant decrease was observed in the serum levels of triglycerides (TG, P~ O. 05) and apolipoprotein A I(apo A I , P<0. 05) during treatment cycles. However these values increased again at the end of the 12th cycle. High density lipoprotein 2-cholesterel (HDL2) decreased significantly (P<0. 05), only during the 8rd and 12th cycle. These results indicate that Sino-implants containing LNG exerts an influence on reducing the levels of TG,apo A I and HDL,, but those values could return gradually as the released drug dose decreased and then became unchanged. On the other hand, the mechanism of the low HDL2-C level induced by Sino-implant is different from that of low HDL2-C level in patients with coronary heart disease. The conclusion is: there is no obvious side effect on lipid metabolism during treatment with the Sino-implant.