The clinical effects of dosage during the period of treatment of Lithospermum Ruderale extract—α kind of Chinese traditional herbal medicine—on medicinal abor-tion induced by mifepristone and misoprostol were studied. Lithospermum Ruderale extract was administrated 3d before, 3d after or 3d before plus 3d after the admin-istration of misoprostol respectively. The dose of Lithospermum Ruderale extract was 50g, 75g or 100g respectively. Thus 1 350 women of early pregnancy were grouped into 9 groups and observed. The results showed that the effects of Lithospermum Rud-erale used 3d before, and 3 d before plus 3d after ( 6 days misoprostol were signifi-cantly better than those only used 3d after misoprostol both for complete abortion and bleeding (P< 0. 05). The dosage between 50g and 100g made no significant differ-ence in clinical effects. Therefore it is reasonable to use 50g Lithospermum Ruderale before misoprostol to improve medicinal abortion.
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