Neural stem cell transplantation in the repair of spinal cord injury

摘要

＜正＞ Neural stem cells are a promising candidate for neural transplantation aimed at neural cell replacement and repair of the damaged host central nervous system （CNS）. Recent studies using neural stem cells have shown that implanted neural stem cells can effectively incorporate into the damaged CNS and differentiate into neurons, astro-cytes, and oligodendrocytes. The recent explosion in the field of neural stem cell research has provided insight into the inductive factors influencing neural stem cell differentiation and may yield potential therapies for several neurological disorders, including spinal cord injury. In this review, we summarize recent studies involving neural stem cell biology in both rodents and humans. We also discuss unique advantages and possible mechanisms of using neural stem cell transplantation in the repair of spinal cord injury.