Objective: To investigate the role and the rules of Tumor necrosis factor alpha and C-reactive protein of patients after surgical treated with small bone with supratentorial hypertensive cerebral hemorrhage and relation with the GCS. Methods: 38 cases diagnosed supratentorial hypertensive intracerebral hemorrhage were given surgery underwent eraniotomy with small bone window after a clear indication. The levels of CRP and TNF-αwere detected before and at 1 day, 7 days and 14 days after surgical treatment, and the Glasgow coma score (GCS) also determination. We also have 30 cases as control of the CRP and TNF-α. Results: Preoperative serum CRP and TNF-α levels were significantly higher than the control group. Postoperative CRP and TKF-α levels continued to rise,but decreased after 7 days of surgical treatment. The levels of CRP and TNF-α are closely associated with the GCS score. Conclusions: CRP and TNF-α levels may reflect patient's condition and prognostic with hypertensive intracerebral hemorrhage.%目的:探索幕上高血压脑出血术前及小骨窗开颅术后C反应蛋白(CRP)及肿瘤坏死因子α(TNF-α)的变化与病情的关系及对患者临床预后的预测价值.方法:38例诊断为幕上高血压脑出血的患者,在明确手术指征后行小骨窗开颅术,于术前,术后第1天,第7天,第14天监测患者的CRP及TNF-α的水平；并同时测定格拉斯哥昏迷评分(GSS).另设30例作为正常对照病例,一次性抽取静脉血进行CRP及TNF-α进行检测.结果:①术前脑出血患者血中CRP与TNF-α的水平显著高于正常对照组；②术后CRP与TNF-α的水平仍继续上升,术后第7天显著下降；③CRP及TNF-α的水平与GCCS评分密切相关.结论:CRP与TNF-α的水平可反映脑出血患者的病情,对病情转归有预测意义.
展开▼
