骨形态发生蛋白-2 (bone morphogentic protein-2, BMP-2)是转化生长因子-β家族的成员,可促进骨髓间充质干细胞分化为成骨细胞和软骨细胞。脱矿牙本质基质(demineralized dentin matrix, DDM)是由牙本质经过粉碎、脱矿、灭菌等处理后制得,具有良好的骨诱导性、骨传导性和生物相容性等特性,是一种颇有前景的骨移植材料。DDM不仅是一种骨移植材料,也可作为重组人骨形态发生蛋白-2 (recombinant human bone morphogentic protein-2, rhBMP-2)的合适载体。DDM与rhBMP-2有着较好的亲和力,并能够缓释rhBMP-2。此外,外源性的rhBMP-2和DDM中内源性BMP具有协同效应,可产生更多的新骨。DDM用作rhBMP-2载体时,rhBMP-2的浓度可降低为0.2 mg/mL。Bone morphogenetic protein-2 (BMP-2) is a transforming growth factor-β family member. It can promote bone marrow mesenchymal stem cells to differentiate into osteoblasts and chondrocytes. Demineralized dentin matrix (DDM) is prepared from dentin after grinding, demineralization, steri-lization, etc. It has good osteoinductive, osteoconductive, biocompatibility, and is a promising bone graft material. DDM is not only a bone graft material, but also a suitable carrier for recombinant human bone morphogenetic protein-2 (rhBMP-2). DDM has good affinity with rhBMP-2 and can slowly release rhBMP-2. In addition, exogenous rhBMP-2 and endogenous BMP in DDM have syner-gistic effects, which can produce more new bones. When DDM is used as rhBMP-2 carrier, the con-centration of rhBMP-2 can be reduced to 0.2 mg/mL.
展开▼
