联合应用左旋氧氟沙星和头孢呋辛治疗慢性阻塞性肺疾病急性发作的疗效观察

摘要

Objective:To research and analysis the clinical efficacy of levofloxacin combine with cefuroxime for chronic obstructive pulmonary disease exacerbations. Methods:Nighty cases with chronic obstructive pulmonary disease exacerbations from January 2011 to December 2013 were randomly divided into observation group and control grou,45 patients in each group,the control group received levofloxacin treatment,observation group received levofloxacin and cefuroxime combination therapy,the lung function before and after treatment,blood gas analysis laboratory parameters and the clinical efficacy after treatment were observed and compared. Results:The total effective rate in observation group was significantly better than the control group,the data were statistically significant differences(P < 0. 05). The forced respiratory volume(FEV1 )within 1 s af-ter treatment,FEV1 value within the estimated ratio(FEV1% ),FEV1 and forced vital capacity(FVE)ratio(FEV1 / FVE),arte-rial oxygen tension(PaO2 ),arterial carbon dioxide partial pressure(PaCO2 )and white blood cell count(WBC)in two group have received some improvement after treatment,the data has statistically significant before and after treatment(P < 0. 05);and the improvement of the observation group was significantly better than the control group ,it has statistically significant( P <0. 05). Conclusion:The combination of levofloxacin and cefuroxime in the treatment of chronic obstructive pulmonary disease exacerbations,significant clinical effect,can significantly improve patients' lung function,blood gas and other laboratory param-eters.%目的：观察联合应用左旋氧氟沙星和头孢呋辛治疗慢性阻塞性肺疾病急性发作的临床疗效。方法：选取2011年1月—2013年12月期间救治的90例慢性阻塞性肺疾病急性发作患者，随机分成观察组和对照组，各45例。对照组给予左旋氧氟沙星治疗，观察组给予左旋氧氟沙星和头孢呋辛联合治疗，对两组治疗前后肺功能、血气分析实验室指标以及治疗后临床疗效进行观察对比。结果：观察组总有效率显著优于对照组，差异有统计学意义（ P ＜0.05）。两组患者治疗后1 s 内用力呼吸量（FEV1）、FEV1与预计值内的比值（FEV1％）、FEV1与用力肺活量（FVE）的比值（FEV1/ FVE）、动脉血氧分压（PaO2）、动脉血二氧化碳分压（PaCO2）以及血白细胞计数（WBC）均得到一定改善，治疗前后相比差异有统计学意义（P ＜0.05）。且观察组改善情况显著优于对照组，差异有统计学意义（P ＜0.05）。结论：联合应用左旋氧氟沙星和头孢呋辛治疗慢性阻塞性肺疾病急性发作，临床疗效显著，可显著改善患者肺功能、血气等实验室指标。