Objective To explore the correlations between plasma homocysteine ( Hcy ) level and central arterial pressure,severity of coronary artery disease off patients with coronary heart disease. Methods A total of 207 patients with suspected coronary heart disease were selected in the Fifth People′s Hospital of Chengdu from December 2013 to December 2014 , all of them received coronary angiography and were divided into A group(with coronary heart disease,n =98)and B group ( without coronary heart disease, n =109 ), of A group, patients were divided into three subgroups according to involved coronary arteries number:A1 group(involved only one coronary artery,n =29),A2(involved two coronary arteries,n =47),A3 group(involved three coronary arteries,n=22). Clinical data including age,gender,history of diabetes,smoking history,BMI,FPG,TC,TG,LDL-C,BUA,plasma Hcy level and central arterial pressure( systolic pressure and diastolic pressure) was compared between groups A and B, plasma Hcy level and Gensini score were compared among the three subgroups,and correlations between plasma Hcy level and Gensini score,central arterial pressure were analyzed. Results No statistically significant differences of age,gender,positive rate of history of diabetes,positive rate of smoking history,BMI, FPG,TC,TG,LDL-C,BUA was found between groups A and B(P>0. 05),while plasma Hcy level and central arterial pressure(systolic pressure and diastolic pressure)of A group were statistically significantly higher than those of B group(P<0. 05). Plasma Hcy level and Gensini score of A3 group were statistically significantly higher than those of A2 group,and those of A2 group were statistically significantly higher than those of A1 group(P<0. 05). Pearson correlation analysis showed that, plasma Hcy level of patients with coronary heart disease was positively correlated with Gensini score(r =0. 145,P <0. 05), central aortic systolic blood pressure(r=0. 542,P=0. 001),central aortic pulse pressure(r=0. 473,P=0. 002),central aortic diastolic blood pressure(r=0. 384,P=0. 034)and brachial aortic systolic blood pressure(r =0. 293,P =0. 039), respectively,is not statistically significantly linerly correlated with brachial aortic diastolic blood pressure( r =0. 189,P =0. 067)or brachial aortic systolic pulse pressure(r =0. 231,P =0. 059). Conclusion The severities of coronary artery disease of coronary heart disease patients with increased plasma Hcy level are more severe,and plasma Hcy level is positively correlated with central arterial pressure.%目的：探讨血浆同型半胱氨酸（ Hcy）水平与冠心病患者中心动脉压及冠状动脉病变程度的相关性。方法收集2013年12月—2014年12月成都市第五人民医院诊治的疑似冠心病患者207例，均行冠状动脉造影，根据冠状动脉造影结果分为冠心病组（n=98）和非冠心病组（n=109），并根据累及冠状动脉支数将冠心病组患者分为单支病变（n=29）、双支病变（n=47）和三支病变（n=22）。记录两组患者临床资料，包括年龄、性别、糖尿病病史、吸烟史、体质指数、空腹血糖、总胆固醇、三酰甘油、低密度脂蛋白胆固醇、血尿酸、血浆Hcy水平、中心动脉压（收缩压和舒张压）。比较冠心病组不同冠状动脉病变支数患者血浆 Hcy水平与Gensini评分，分析血浆Hcy水平与Gensini评分及中心动脉压之间的相关性。结果两组患者性别、糖尿病病史阳性率、吸烟史阳性率、年龄、体质指数、空腹血糖及总胆固醇、三酰甘油、低密度脂蛋白胆固醇、血尿酸水平比较，差异无统计学意义（ P>0.05）；冠心病组患者血浆Hcy水平和中心动脉压（收缩压和舒张压）高于非冠心病组（ P<0.05）。三支病变患者血浆Hcy水平和Gensini评分高于双支病变患者，双支病变患者血浆Hcy水平和Gensini评分高于单支病变患者（ P<0.05）。Pearson相关分析结果显示，冠心病患者血浆Hcy水平与Gensini积分（r=0.145，P<0.05）、中心动脉收缩压（r=0.542，P=0.001）、中心动脉脉压（r =0.473，P =0.002）、中心动脉舒张压（r =0.384，P =0.034）及肱动脉收缩压（r =0.293，P=0.039）呈正相关，但与肱动脉舒张压（r=0.189，P=0.067）和肱动脉脉压（r=0.231，P=0.059）无明显直线相关性。结论血浆Hcy水平较高的冠心病患者冠状动脉病变程度较严重，且血浆Hcy水平与中心动脉压明显相关。
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