老年高血压并抑郁症与血管紧张素原G-6A位点基因多态性的相关性研究

摘要

目的：探讨老年高血压并抑郁症与血管紧张素原（AGT）基因 G -6A 位点基因多态性的关系。方法选择2010年12月—2013年11月昆明市延安医院干疗/老年病科及云南省精神病院收治的老年高血压患者400例，根据患者是否并发抑郁症分为高血压并抑郁症组和高血压组，各200例；另选取同期就诊于昆明市延安医院体检中心的200例老年体检健康者作为健康对照组。采用基因测序方法检测 AGT 基因 G -6A 位点基因多态性。结果（1）高血压并抑郁症组和高血压组 AGT 基因 G -6A 位点 G/ G 基因型所占比例高于健康对照组、A/ A 基因型所占比例低于健康对照组，高血压并抑郁症组 AGT 基因 G -6A 位点 GG 基因型所占比例高于高血压组（P ＜0.05）。（2）高血压并抑郁症组和高血压组等位基因频率分布分别与健康对照组比较，差异有统计学意义（ P ＜0.05），OR（95% CI）分别为3.389（2.475，4.651）、2.336（1.698，3.215）；高血压并抑郁症组和高血压组等位基因频率分布比较，差异有统计学意义（P ＜0.05），OR（95% CI）为1.452（1.094，1.928）。结论 AGT 基因 G -6A 位点基因多态性与老年高血压并抑郁症遗传易患性有关，携带 AGT 基因 G -6A 位点 G/ G 基因型及 G 等位基因的高血压患者患抑郁症的风险较高，携带 AGT 基因 G -6A 位点 A/ A 基因型及 A 等位基因的人群患高血压及高血压并抑郁症的风险较低。%Objective To investigate the correlation between aged hypertension complicated with depression and angiotensinogen G - 6A gene polymorphism. Methods From December 2010 to November 2013,400 aged hypertension patients were selected in the Department of Geriatrics,Yan'an Hospital of Kunming and Yunnan Provincial Mental Hospital,and they were divided into groups A(with depression)and B(without depression)according to the incidence of depression,each of 200 cases. A total of 200 healthy cases were selected as control group in the Physical Examination center of Yan'an Hospital of Kunming at the same time. Gene sequencing method was used to detect the angiotensinogen G - 6A gene polymorphism. Results The proportion of G/ G genotype of groups A and B were higher than that of control group,respectively,while the proportion of A/ A genotype was lower,respectively(P < 0. 05);the proportion of G/ G genotype of A groups was higher than that of B group (P < 0. 05). There was statistically significant differences of allele frequency among the three groups(P > 0. 05),and the OR (95% cI)of groups A and B was 3. 389(2. 475,4. 651),2. 336(1. 698,3. 215)when compared with control group. There was statistically significant differences of allele frequency between groups A and B( P > 0. 05),and the OR(95% cI) of A group was 1. 452(1. 094,1. 928)when compared with B group. Conclusion angiotensinogen G - 6A gene polymorphism is correlated with the hereditary susceptibility of aged hypertension complicated with depression,G/ G genotype and G allele can increase the risk of depression in hypertension patients,A/ A genotype and A allele can reduce the risk of hypertension and hypertension complicated with depression.