经皮冠状动脉介入术对急性心肌梗死患者血浆基质金属蛋白酶9、白介素6及 P 选择素水平的影响研究

摘要

Objective to investigate the impact of PCI on plasma levels of MMP-9,IL-6 and P - selectin of patients with AMI. Methods From March 2013 to March 2015 in the Central Hospital of Huangshi,a total of 87 patients with AMI were selected as observation group,a total of 52 healthy people were selected as control group. Before PCI,after 6 days and 90 days of PCI,ELISA was used to detect the plasma levels of MMP-9,IL-6 and P - selectin of observation group,while above index of control group were detected on the day for physical examination. Results Plasma levels of MMP-9 and P - selectin of observation group were statistically significantly higher than those of control group before PCI,while plasma IL-6 level of observation group was statistically significantly lower than that of control group before PCI(P < 0. 05);no statistically significant differences of plasma level of MMP-9,IL-6 or P - selectin was found between the two groups after 6 days or 90 days of PCI(P > 0. 05);after 6 days of PCI,plasma levels of MMP-9 and P - selectin of observation group were statistically significantly lower than those before PCI,while plasma IL-6 level of observation group was statistically significantly higher than that before PCI(P < 0. 05);after 90 days of PCI,plasma levels of MMP-9 and P - selectin of observation group were statistically significantly lower than those before PCI(P < 0. 05),while no statistically significant differences of plasma IL-6 level of observation group was found compared with that before PCI(P > 0. 05);after 90 days of PCI,no statistically significant differences of plasma level of MMP-9,IL-6 or P -selectin of observation group was found compared with those after 6 days of PCI(P > 0. 05). Conclusion PCI can effectively adjust the plasma levels of MMP-9,IL-6 and P - selectin of patients with AMI,is helpful to promote their recovery.%目的：探讨经皮冠状动脉介入术（ PCI）对急性心肌梗死（ AMI）患者血浆基质金属蛋白酶9（MMP-9）、白介素6（IL-6）及 P 选择素水平的影响。方法选择黄石市中心医院2013年3月—2015年3月收治的87例 AMI 患者作为观察组，同期在该院体检并与观察组患者年龄相近的52例健康者作为对照组。采用酶联免疫吸附法（ELISA）检测观察组患者 PCI 前、PCI 后6 d 及 PCI 后90 d，对照组受检者体检当天血浆MMP-9、IL-6、P 选择素水平。结果观察组患者 PCI 前血浆MMP-9、P 选择素水平高于对照组，血浆IL-6水平低于对照组（P <0.05）；观察组患者PCI 后6 d、术后90 d 血浆MMP-9、IL-6、P 选择素水平与对照组比较，差异无统计学意义（P >0.05）；观察组患者PCI 后6 d 血浆MMP-9、P 选择素水平低于 PCI 前，血浆IL-6水平高于 PCI 前（P <0.05）；观察组患者 PCI 后90 d 血浆MMP-9、P 选择素水平低于 PCI 前（P <0.05），而血浆IL-6水平与 PCI 前比较，差异无统计学意义（P >0.05）；观察组患者 PCI 后90 d 血浆MMP-9、IL-6、P 选择素水平与 PCI 后6 d 比较，差异无统计学意义（P >0.05）。结论 PCI 可有效调节 AMI 患者血浆MMP-9、IL-6、P 选择素水平，促进其恢复正常。