骨质疏松患者部分骨代谢指标测定的临床意义

摘要

目的 研究血清Ⅰ型胶原氨基末端肽(NTx)和Ⅰ型胶原羧基末端肽(CTx)等指标的检测对于中老年骨质疏松患者的意义. 方法 对165例中老年患者行双能X线骨密度检查,同时检测其血清NTx、CTx、骨型碱性磷酸酶(BAP)、Ⅰ型前胶原氨基末端肽(PINP)、骨钙素(BGP)、白细胞介素6(IL-6)及肿瘤坏死因子α(TNFα),100例体检人员作为对照. 结果 骨质疏松患者BGP和IL-6明显高于对照组(P＜0.05)而TNF-α则与对照组无显著差异.骨质疏松组血清BAP和PINP显著低于对照组和骨量减少组(P＜0.05),NTx及CTx则显著高于对照组和骨量减少组(P＜0.05)；而骨量减少组NTx、CTx明也显高于对照组(P＜0.05). 结论 血清NTx和CTx可作为骨吸收的特异性指标,对骨质疏松患者的诊断和疗效评估均具有重要意义.%Objective To investigate the value of the determination of bone metabolism parameters, such as type I collagen amino-terminal peptide(NTx) or carboxy-terminal peptide(CTx) , in the patients with osteoporosis. Methods To determine the bone mineral density, 165 patients were checked with lunar DEXA instrument. The serum NTx, CTx, bone alkaline phosphatase( BAP), type Ⅰ procollagen amino-terminal peptide( P1NP), bone gamma carboxyglutamic-acid-containing proteins( BGP), IL-6 and TNF-α were measured with ELISA or ECL. The control group contained 100 healthy people. Results The levels of BGP, IL-6, NTx, CTx in patients with osteoporosis were significantly higher than those in healthy people. The level of serum TNF-α showed no significant differences between patients with osteoporosis and healthy people. The levels of serum BAP and PINP in patients with osteoporosis were significantly lower than those in healthy people. Conclusions As the specific bone resorption signs, NTx and CTx are very important in diagnosis and treatment for osteoporosis.