SYNTHESIS AND PHASE BEHAVIOR OF POLYURETHANES END-CAPPED WITH FLUORINATED PHOSPHATIDYLCHOLINE HEAD GROUPS

摘要

A series of fluorinated phosphatidylcholine polyurethane macromolecular additives were synthesized by solution polymerization using methylenebis(phylene isocyanates)(MDI) and 1,4-butanediol(BDO) as hard segments,a new phoshporycholine,2-(2,2,3,3,4,4,5,5,6,6,7,7,8,8,9,9-hexadecafluoro-10-(2-hydroxyethoxy)decyloxy) ethyl phosphorycholine (HDFOPC) as end-capper,and four polydiols,poly(tetramethylene glycol)s(PTMG),polydimethylsiloxane(PDMS), poly(1,6-hexyl-1,5-pentylcarbonate)(PHPC) and poly(propylene glycol)(PPG) as soft segments,respectively.The chemical structures of the synthesized polyurethanes were characterized by ~1H-NMR and FTIR.DSC and DMA were employed to study the phase behavior of these novel polyurethanes due to their great influences on the surface properties,and hence their interactions with bio-systems.The results showed that phase separation of the fluorinated phosphatidylcholine end-capped polyurethanes was increased in comparison with that of normal polyurethanes.The effect of fluorinated phosphatidylcholine end-capped groups on the phase behavior was further demonstrated by analyzing the degree of hydrogen-bonding between hard and soft segments.