Modulation of MMP-2 and TIMP-2 by low dose radiation in mice bearing S180 sarcoma

摘要

Objective To investigate the inhibition of low dose radiation(LDR) on S180 sarcomas and its modulation of MMP-2 and TIMP-2 in mice.Methods S180 subcutaneously implanted tumor model mice were randomly divided into two groups: control(N) and low dose radiation(LDR) groups. N mice were sacrificed after 12 h, whereas LDR mice were sacrificed after 12(LDR-12 h), 24(LDR-24 h), 48(LDR-48 h), and 72(LDR-72 h) h. Thereafter, we measured the tumor volumes. Histopathology was performed, and P-V immunohistochemistry was applied to assess MMP-2 and TIMP-2 expression.Results Compared with the control group, the tumor growth was significantly inhibited in the LDR groups(P 0.05) in contrast to that of the control group.Conclusion LDR can effectively suppress the growth of S180 implanted tumors by reducing MMP-2, which is associated with invasion and metastasis.