Expression and clinical significance of MCM5 and P16 in hyperplastic disease of the cervix

摘要

Objective The aim of the study was to study the expression and clinical significance of MCM5 and P16 in cervical intraepithelial neoplasia(CIN)and cervical cancer.Methods The immunohistochemistry S-P method was used to detect the expression of MCM5 and P16 in 100 cases of cervical CIN and cancer.Results The positive expression rates of MCM5 and P16 in normal cervical epithelium,CIN I,CIN II,CIN III,and cervical invasive cancer were 6.7%,35.0%,40.0%,70.0%,and 97.5%,and 6.7%,30.0%,45.0%,75.0%,and 100%,respectively.The positive expression rates of MCM5 and P16 significantly differed between CIN and infiltrating carcinoma(P<0.05).The expression levels of MCM5 and P16 positively correlated in cervical cancer(P<0.01).The positive expression of MCM5 and P16 closely correlated with the clinical stage and pathological grade of cervical cancer(P<0.05).Conclusion MCM5 and P16 might be used as markers for aggressive biological behavior in cervical cancer and might be useful for distinguishing CIN and cervical cancer.