控制粉针剂药物静脉输注过程中的损失量

摘要

To approach the drug losses in the course of powder injection intravenous infusion, Sodium Cefazolin was determined in the whole course of infusion including quantitative solvent dilution, the losses of empty ampule and rinsing of infusion bottle. It was determined through ultraviolet spectrophotometry. Results showed that in the whole course of infusion, the drug loss was 0. 516 g + 0.09 g.It accounted for 12.9% of total administrative medicine. It also showed that the drug loss was more in randomly using solvent than that in quantitatively solvent dilution and rinsing the empty ampule and infusion bottle once. Suggested that when one infuse powder medicine, one would dilute powder injection with quantitative solvent according to the ampule volume. And it may decrease the drug losses if one rinsed the empty ampule or infusion bottle once.%为进一步探讨静脉输注粉针剂药物过程中药物损失量，以头孢唑啉钠为例，对静脉输注过程、定量溶媒稀释、空药瓶及输液瓶冲中洗1次后药物损失量，采用紫外分光光度法进行测定。结果：静脉输注全过程药物损失量为0.516 g±0.09 g，占用药量的12.9％；随机采样药物损失量高于4ml定量溶媒溶解及冲洗1次空药瓶和输液瓶的药物损失量。提示：在静脉输注粉针剂药物时，应根据药瓶容积定量溶媒稀释、冲洗1次空药瓶及输液瓶，可减少药物损失量。