Impact of alpha-synuclein pathology on adult neurogenesis: evidence for multilayered mechanisms

摘要

Parkinson’s disease(PD)is the second most common neurodegenerative disease affecting 8–10 million people worldwide.Moreover,PD is the fastest-growing neurodegenerative disease and it is predicted that the number of patients will double in the next thirty years.Neuropathologically,PD is characterized by the presence of protein aggregations called Lewy bodies(LB)and by degeneration of dopaminergic neurons in the substantia nigra pars compacta.