Deciphering the transcriptomic signature of synaptic activity

摘要

Neurons undergo activity-dependent changes in their molecular composition and structure in order to regulate cellular processes such as dendritic growth,synapse elimination,spine maturation and synaptic strength.Such synaptic plasticity plays an important role during a critical period in brain development and contributes to sensory adaptation and to learning and memory in the mature nervous system.Its dysregulation underlies a number of pathological processes in psychiatric and neurodegenerative disorders,such as addiction.