Organotypic hippocampal slices,an emerging tool to model synucleinopathies

摘要

Parkinson’s disease(PD)is the second most common neurodegenerative disease after Alzheimer’s disease.PD has been traditionally considered a motoric disorder characterized by tremor,rigidity and bradykinesia,however it is now settled that PD also comprises a range of non-motor symptoms like hyposmia,sleep disturbances and cognitive impairments(Tysnes and Storstein,2017).