Environmental enrichment promotes neural remodeling in newborn rats with hypoxic-ischemic brain damage

摘要

We evaluated the effect of hypoxic-ischemic brain damage and treatment with early environmental enrichment intervention on development of newborn rats,as evaluated by light and electron mi-croscopy and morphometry.Early intervention with environmental enrichment intelligence training attenuated brain edema and neuronal injury,promoted neuronal repair,and increased neuronal plasticity in the frontal lobe cortex of the newborn rats with hypoxic-ischemic brain damage.