Curcumin reduces inflammatory reactions following transient cerebral ischemia/reperfusion injury

摘要

Inflammatory reactions are important pathophysiological mechanisms of ischemic brain injury.The present study analyzed the anti-inflammatory characteristics of curcumin via myeloperoxidase activity and nitric oxide content after 2-hour ischemia/24-hour reperfusion in Sprague Dawley rats.In addition,expressions of nuclear factor kappa B,tumor necrosis factor-α and interleukin-1β protein were measured.Curcumin significantly reduced myeloperoxidase and nitric oxide synthase activities and suppressed expressions of nuclear factor kappa B,tumor necrosis factor-α,and interleukin-1β in ischemia/reperfusion brain tissue.Results suggested that the neuroprotective effect of curcumin following cerebral ischemia/reperfusion injury could be associated with inhibition of inflammatory reactions.