Spinal cord organoids add an extra dimension to traditional motor neuron cultures

摘要

Since Lancaster et al.(2013)first described the formation of self-organizing cerebral organoids for modeling neurodevelopmental disorders,it became evident that three-dimensional(3D)neural organoid cultures are more superior systems for modeling neurodevelopment and neurodegeneration in human.The use of a spinning bioreactor to grow organoids allows better nutrient absorption and enhances formation of neuroepithelial-like zones,making it a great tool to study neurodevelopment and neurodegeneration.Neural organoids are 3D cell culture systems formed by proliferating,differentiating,migrating and self-organizing pools of neural progenitors.They mimic brain structures in their cell type composition,cytoarchitecture,and to some extent maturity and functionality(Lancaster et al.,2013).Because of these unique.