首页> 中文期刊> 《中国神经再生研究:英文版》 >Spinal cord organoids add an extra dimension to traditional motor neuron cultures

Spinal cord organoids add an extra dimension to traditional motor neuron cultures

         

摘要

Since Lancaster et al.(2013)first described the formation of self-organizing cerebral organoids for modeling neurodevelopmental disorders,it became evident that three-dimensional(3D)neural organoid cultures are more superior systems for modeling neurodevelopment and neurodegeneration in human.The use of a spinning bioreactor to grow organoids allows better nutrient absorption and enhances formation of neuroepithelial-like zones,making it a great tool to study neurodevelopment and neurodegeneration.Neural organoids are 3D cell culture systems formed by proliferating,differentiating,migrating and self-organizing pools of neural progenitors.They mimic brain structures in their cell type composition,cytoarchitecture,and to some extent maturity and functionality(Lancaster et al.,2013).Because of these unique.

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