Identification of a microRNA switch in spinal commissural axon guidance

摘要

The formation of neural circuits is governed by multiple classes of highly conserved extracellular guidance signals such as guidance cues,growth factors,and cell adhesion molecules(Kolodkin and Tessier-Lavigne,2011;Stoeckli et al.,2018).During embryonic development,vertebrate commissural neurons project axons toward the floor plate and cross the midline of the spinal cord,a process relying upon the coordination of attractive and repulsive guidance cues(Kolodkin and Tessier-Lavigne,2011;Stoeckli et al.,2018).