Bilateral olfactory ensheathing cell transplantation promotes neurological function in a rat model of cerebral infarction

摘要

In the present study,olfactory ensheathing cells were transplanted into the cortices of infarcted(infarct transplantation group),normal(normal transplantation group),and bilateral hemispheres(bilateral transplantation group).Olfactory ensheathing cells migrated to the infarct focus.The number of growth associated protein 43-positive cells and nerve fibers was slightly increased in the infarct area.These changes were more evident in the bilateral cortical transplantation group.Results demonstrated that transplanted olfactory ensheathing cells can migrate in rats with cerebral infarction.The olfactory ensheathing cells on the normal side can also promote neurological function.Bilateral cortical transplantation exhibited superior effects over unilateral transplantation.