Influence of electroacupuncture on mitogen-activated protein kinase signal transduction in a rat model of cerebral ischemia/reperfusion

摘要

Following electroacupuncture at Baihui (DU 20) and Dazhui (DU 14) in a rat model of cerebral ischemia/reperfusion,extracellular-signal-regulated kinase expression in cerebral cortex and corpus striatum,serum glutathione reductase,glutathione peroxidase activity,and serum glutathione content were elevated,and neurobehavioral scores improved.However,these effects were antagonized by mitogen-activated protein kinase inhibitor PD98059.Results indicated that electroacupuncture reversed free radical chain reactions and oxidative stress injury caused by cerebral ischemia/reperfusion,thereby providing neuroprotection.This process could correlate with the mitogen-activated protein kinase signal transduction pathway.