The present study established a rabbit model of global cerebral ischemia using the 'six-vessel' method,which was reperfused after 30 minutes of ischemia.Rabbits received intravenous injection of propofol at 5 mg/kg prior to ischemia and 20 mg/kg per hour after ischemia until samples were prepared.Results revealed that propofol inhibited serum interleukin-8,endothelin-1 and malondialdehyde increases and promoted plasma superoxide dismutase activity after cerebral ischemia/reperfusion.In addition,cerebral cortex edema was attenuated with little neuronal nuclear degeneration and pyknosis with propofol treatment.The cross-sectional area of neuronal nuclei was,however,increased following propofol treatment.These findings suggested that propofol could improve anti-oxidant activity and inhibit synthesis of inflammatory factors to exert a protective effect on cerebral ischemia/reperfusion injury.
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