Multiple reaction monitoring for the detection of disease-related synaptic proteins

摘要

Synaptic dysfunction occurs early in Alzheimer’s disease(AD)and is acknowledged as a primary pathologic target for treatment.Synaptic degeneration is the pathological feature most strongly correlated with loss of cognitive function ante mortem(Terry et al.,1991).Synapses are heavily damaged in hippocampal and neocortical regions of AD brain,whereas motor and occipital cortices are relatively spared(Honer et al.,1992).Despite extensive work,the molecular mechanisms underlying synaptic degeneration are largely unknown.