Pathogenesis of glaucoma: how to prevent ganglion cell from axonal destruction?

摘要

Glaucoma is the main cause of irreversible blindness globally,but the pathogenesis of glaucoma is still pending consensus.In spite of great advances during the 20th and early 21st centuries in terms of detailed knowledge of pathological processes that take place in glaucoma,the exact pathogenesis is much less clear.Hypotheses abound,and the most researched areas are ischemia at the optic nerve head,blockade of ganglion cell axonal transport,peripapillary atrophy,and changes in the characteristics of the lamina cribrosa(Nucci et al.,2008).