Methylation reactions at dopaminergic nerve endings, serving as biological off-switches in managing dopaminergic functions

摘要

The mechanisms for the regulation of synaptic dopamine(DA)include its release from presynaptic vesicles,its interaction with post-synaptic and pre-synaptic DA receptors,the reuptake of DA,via dopamine transporter(DAT),the diffusion of DA and its metabolism by mono-amine oxidase(MAO)and catechol-O-methyl transferase(COMT).DA controls complex