Purinergic signalling,adenosine 5′-triphosphate(ATP)as an extracellular signalling molecule,was proposed in 1972(Burnstock,1972).However,it was not generally accepted until the early 1990s when receptors for ATP and its breakdown product adenosine were cloned and characterised(Ralevic and Burnstock,1998).Four P1(adenosine)receptors are recognised(A1,A2A,A2B and A3),seven
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