Fractalkine: multiple strategies to counteract glutamate receptors activation leading to neuroprotection

摘要

Glutamate(Glu)is the main excitatory amino acid in the brain and plays a pivotal role in many neurophysiological functions.Nevertheless,an excess and prolonged exposure to Glu determines the overactivation of glutamate receptors(Glu Rs)with consequent impairment of cellular calcium(Ca2+)homeostasis,leading to the dysregulation of intracellular pathways and resulting in neuronal dysfunction