Okadaic acid：a tool to study regulatory mechanisms for neurodegeneration and regeneration in Alzheimer’s disease

摘要

Okadaic acid:Okadaic acid(OKA),a polyether(C38 fatty acid)toxin,is a potent and selective inhibitor of protein phosphatase,PP1 and protein phosphatase 2A(PP2A).It is mainly extracted from a black sponge Hallichondria okadaii and has been suggested to play a potent probe for studying the various molecular,cellular,biochemical and