Not only a bad guy: potential proneurogenic role of the RAGE/NF-κB axis in Alzheimer's disease brain

摘要

The receptor for advanced glycation endproducts(RAGE)is a receptor of the immunoglobulin superfamily of cell surface molecules which plays important contributions under both physiological and pathological conditions.Over the years extensive research work supported the detrimental role of RAGE in Alzheimer’s disease(AD)pathophysiology,ranging from its involvement in beta amyloid(Aβ)brain influx and clearance,