An open-label pilot study with high-dose thiamine in Parkinson's disease

摘要

Parkinson’s disease(PD)is a progressive neurodegenerative disorder clinically characterized by motor symptoms(bradykinesia,tremor,rigidity,postural instability)and non-motor symptoms(hyposmia,sleep disorders,autonomic and sphincteric dysfunctions,fatigue,pain,depression,and cognitive disorders)(Sprenger and Poewe,2013).The neuropathological hallmark of PD is