Amyloid peptide(Aβ)oligomers are considered one of the primary causal factors for the synaptic loss characteristic of Alzheimer’s disease(AD)(Karran and De Strooper,2016).However,Aβis generated in normal brains and accumulates at synaptic sites,which raises the question whether Aβplays a physiological role in synapses.This unresolved issue is especially relevant in view
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