Amyotrophic lateral sclerosis disease modifying therapeutics:a cell biological perspective

摘要

Amyotrophic lateral sclerosis(ALS)is a progressively fatal neuromuscular disorder classically characterized by loss of upper and lower motor neurons from the cortex to the spinal cord Diagnosed patients have a median survival of about 3 years and death usually results from eventual respiratory failure.The motor neuron disorder is clinically complex,and its diverse clinica presentations and multiple deciphered underlying