Challenges and opportunities identifying therapeutic targets for chemotherapy-induced peripheral neuropathy resulting from oxidative DNA damage

摘要

Background on chemotherapy-induced peripheral neuropathy(CIPN)Incidence,prevalence,and consequences:Up to 90%of cancer patients experience CIPN at some point during or after anticancer treatment(Seretny et al.,2014).Although CIPN is second to hematologic toxicities in regards to the frequency of incidence,