Ternary Pd-Ni-P nanoparticle-based nonenzymatic glucose sensor with greatly enhanced sensitivity achieved through active-site engineering

摘要

We develop a unique ternary Pd-Ni-P nanocatalyst for the sensitive enzymefree electrooxidation detection of glucose under alkaline conditions.By reducing the distance between the Pd and Ni active sites in the Pd-Ni-P nanoparticles (NPs) via atom engineering,the catalyst structure is transformed from Pd@Ni-P dumbbells into spherical NPs,greatly enhancing the catalyst sensitivity.The glassy carbon electrode modified with Pd-Ni-P ternary NPs,which behaves as an efficient nonenzymatic glucose sensor,offers excellent electrocatalytic performance with a high sensitivity of 1,136 μA·mM-1·cm-2,a short response time of 2 s,a wide linear range of 0.5 ~ to 10.24 mM,a low limit of detection of 0.15 μM (signal-to-noise ratio =3),and good selectivity and reproducibility.Moreover,owing to its superior catalytic performance,the Pd-Ni-P modified electrode has excellent reliability for glucose detection in real samples of human serum.Our study provides a promising alternative strategy for designing and constructing high-performance multicomponent nanocatalyst-based sensors.