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Cell Membrane Coating Technology:A Promising Strategy for Biomedical Applications

         

摘要

Cell membrane coating technology is an approach to the biomimetic replication of cell membrane properties,and is an active area of ongoing research readily applicable to nanoscale biomedicine.Nanoparticles(NPs)coated with cell membranes offer an opportunity to unite natural cell membrane properties with those of the artificial inner core material.The coated NPs not only increase their biocompatibility but also achieve effective and extended circulation in vivo,allowing for the execution of targeted functions.Although cell membrane-coated NPs offer clear advantages,much work remains before they can be applied in clinical practice.In this review,we first provide a comprehensive overview of the theory of cell membrane coating technology,followed by a summary of the existing preparation and characterization techniques.Next,we focus on the functions and applications of various cell membrane types.In addition,we collate model drugs used in cell membrane coating technology,and review the patent applications related to this technology from the past 10 years.Finally,we survey future challenges and trends pertaining to this technology in an effort to provide a comprehensive overview of the future development of cell membrane coating technology.

著录项

  • 来源
    《纳微快报:英文版》 |2019年第4期|P.720-765|共46页
  • 作者单位

    Science and Technology Innovation Center Guangzhou University of Chinese Medicine Guangzhou 510405 People’s Republic of ChinaInstitute of Clinical Pharmacology Guangzhou University of Chinese Medicine Guangzhou 510405 People’s Republic of China;

    Science and Technology Innovation Center Guangzhou University of Chinese Medicine Guangzhou 510405 People’s Republic of ChinaInstitute of Clinical Pharmacology Guangzhou University of Chinese Medicine Guangzhou 510405 People’s Republic of China;

    State Key Laboratory of Quality Research in Chinese Medicine Institute of Chinese Medical Sciences University of Macau Macau People’s Republic of China;

    Key Laboratory of Artificial Micro-and Nano-Structures of Ministry of Education School of Physics and Technology Wuhan University Wuhan 430072 People’s Republic of China;

    Science and Technology Innovation Center Guangzhou University of Chinese Medicine Guangzhou 510405 People’s Republic of ChinaInstitute of Clinical Pharmacology Guangzhou University of Chinese Medicine Guangzhou 510405 People’s Republic of China;

  • 原文格式 PDF
  • 正文语种 chi
  • 中图分类 制剂学;
  • 关键词

    Cell membrane; Biomimetic nanoparticles; Cancer therapy; Immune modulation; Detoxification;

    机译:细胞膜;仿生纳米粒子;癌症治疗;免疫调节;排毒;
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