P-Loop-Dependent NLR SNC1 Can Oligomerize and Activate Immunity in the Nucleus

摘要

Dear Editor, Upon recognition of pathogen effectors,plant resistance (R) proteins trigger strong defense responses that restrict the growth and spread of pathogens.Most R proteins are nucleotide-binding (NB) and leucine-rich repeat (LRR) domain-containing proteins (NLRs) sharing structural similarity with animal NOD-like receptors (Dodds and Rathjen,2010).SNC1 (Suppressor of npr1,constitutive 1) is an Arabidopsis Toll/interleukin-1 Receptor (TIR)-type NLR that was originally identified through a gain-of-function autoimmune mutant,snc1,from a forward genetic screen.