荜茇及其有效成分降脂抗动脉粥样硬化研究概况

摘要

Based on the literature search both in China and abroad, this article reviewed the research situation on blood lipid-lowering and anti-atherosclerosis function of Piper longum and its effective ingredients. The study results showed that Piper longum and its effective ingredients, such as piperine and piperlonguminine, have obvious blood lipid-lowering function. And piperlonguminine, is especially effective in lowering blood lipid and anti-atherosclerosis with very low toxin. Piper longum is a promising material for the future blood lipid-lowering compound development.This review also provided references for the further research and development in this aspect.%本文综述了国内外有关荜茇及其有效成分的降脂、抗动脉粥样硬化方面的研究进展,并结合本课题组的研究结果,认为荜茇及其有效成分胡椒碱、荜茇宁等具有显著的降血脂作用,特别是荜茇宁不仅降脂、抗动脉粥样硬化作用显著,而且毒性极低,是极具开发前景的降脂化合物.荜茇宁的作用机制可能是通过提高高脂血症大鼠肝脏LDLR基因表达,降低ApoB基因表达而起到降脂作用;通过调节脂代谢紊乱、增强抗氧化酶类活性、减轻脂质过氧化物对血管内皮的损伤、降低主动脉LOX-1和VCAM-1基因表达起到抗动脉粥样硬化作用.